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Circulating cell-free DNA (ccfDNA)

An important biomarker for non-invasive prenatal testing (NIPT) and liquid biopsy, circulating cell-free DNA (ccfDNA) is easily obtainable through a simple blood draw. ccfDNA from plasma has the ability to provide a breadth of information to researchers.

Did you know?

  • ccfDNA is present in low quantity in blood
  • ccfDNA can be further diluted by genomic DNA (gDNA) from apoptotic or lysed blood cells
  • The type of anticoagulant and crosslinking reagents in blood collection tubes can impact the quality of ccfDNA

Standardize your workflow with the PAXgene Blood ccfDNA System (RUO)*
to preserve the ccfDNA profile in your blood sample

Blood collection, stabilization and ccfDNA extraction for reliable downstream assay performance

Multimodal Liquid Biopsy Analysis from blood samples collected in PAXgene Blood ccfDNA Tubes

Check out our poster presented at the AACR Virtual Meeting II

Stabilization chemistry matters

Learn about the non-crosslinking stabilization chemistry in the PAXgene Blood ccfDNA Tube and how other tubes may impact analytical sensitivity in downstream reactions.

Explore ccfDNA, CTCs and gDNA from the same sample

Five minute read on how to perform multimodal analysis from a single blood sample. Learn how to extract and analyze ccfDNA and additional analytes like RNA from CTCs or gDNA from a single sample of blood collected in the PAXgene Blood ccfDNA Tube*.

Trusted quality samples with PreAnalytiX

Learn more about optimal quantification methods, reliable stability claims and long shelf life of the PAXgene Blood ccfDNA Tube* which is backed by robust data.  

Research Applications

Non-invasive prenatal testing (NIPT)

Researchers in the field of non-invasive prenatal testing analyze fetal DNA present among maternal ccfDNA from blood of a pregnant woman to determine the risk that the fetus will be born with certain genetic abnormalities.

Liquid Biopsy

Liquid biopsy is a minimally-invasive method of collecting a patient biofluid sample to test for biomarkers of disease. Liquid biopsy is commonly used for many applications in cancer research.

Click here to learn more about QIAGEN's manual and automated Sample to Insight workflows for liquid biopsy and cancer research applications.

Meet our experts on upcoming events to discuss the possibilities how to optimize your preanalytical workflows

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Watch our recent ccfDNA webinar focusing on "Special considerations in preparing circulating cell-free DNA samples"

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Discover our variety of scientific posters which were presented at conferences around the world

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*The PAXgene Blood ccfDNA Tube is for Research Use Only. Not for use in diagnostic procedures.


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