PreAnalytiX: See here how NIH GTEx project successfully used the PAXgene Tissue System for tissue fixation and nucleic acid isolation from various sample types

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        06/18/2024 | Publications Saliva RNA
        See here how NIH GTEx project successfully used the PAXgene Tissue System for tissue fixation and nucleic acid isolation from various sample types
        June 2024
        Have you heard before of the Common Fund´s Genoytpe-Tissue Expression (GTEx) Program of the National Institutes of Health (NIH)? It was established as a data resource and tissue bank to study the relationship between genetic variants (inhered changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals.
        GTEx collected approximately 40 different tissues types (i.e. brain, heart, lung, breast, skin and whole blood etc.) from nearly 1000 postmortem donors and over 30,000 samples. The developed biobank serves as a respository for GTEx biospecimen whereas most samples are preserved as PAXgene-fixed (PF), frozen samples, PAXgene-fixed, paraffin-embedded (PFPE) blocks used for histological examination or RNA from PF-tissue for RNA sequencing. The GTEx biobank also features an electronic image library of the tissue samples for researchers to browse the complete collection. Tissue-specific differences in the severity of autolysis, tissue purity and RNA integrity were evaluated, as were potential relationships between these markers and the duration of postmortem interval and rapidity of death.
        The below publication summarizes the tissue-specific challenges in the procurement and preservation of the nearly 30,000 tissue specimens collected during the GTEx project. Furthermore, differences in the degree of autolysis and RNA integrity number were observed among the 40 tissue types evaluated, and tissue-specific susceptibilities to the duration of postmortem interval and rapidity of death were observed.
        Histologic and Quality Assessment of Genotype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection
        Leslie Sobin, MD; Mary Barcus, MD; Philip A. Branton, MD; Kelly B. Engel, PhD; Judy Keen, PhD; David Tabor, BA; Kristin G. Ardlie, PhD; Sarah R. Greytak, PhD; Nancy Roche, PhD; Brian Luke, PhD; Jim Vaught, PhD; Ping Guan, PhD; Helen M. Moore, PhD
        Arch Pathol Lab Med (2024)
        https://doi.org/10.5858/arpa.2023-0467-OA
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        DNA PAXgene Saliva Collector (MBA)
        06/18/2024 | Publications Saliva RNA
        See here how NIH GTEx project successfully used the PAXgene Tissue System for tissue fixation and nucleic acid isolation from various sample types
        June 2024
        Have you heard before of the Common Fund´s Genoytpe-Tissue Expression (GTEx) Program of the National Institutes of Health (NIH)? It was established as a data resource and tissue bank to study the relationship between genetic variants (inhered changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals.
        GTEx collected approximately 40 different tissues types (i.e. brain, heart, lung, breast, skin and whole blood etc.) from nearly 1000 postmortem donors and over 30,000 samples. The developed biobank serves as a respository for GTEx biospecimen whereas most samples are preserved as PAXgene-fixed (PF), frozen samples, PAXgene-fixed, paraffin-embedded (PFPE) blocks used for histological examination or RNA from PF-tissue for RNA sequencing. The GTEx biobank also features an electronic image library of the tissue samples for researchers to browse the complete collection. Tissue-specific differences in the severity of autolysis, tissue purity and RNA integrity were evaluated, as were potential relationships between these markers and the duration of postmortem interval and rapidity of death.
        The below publication summarizes the tissue-specific challenges in the procurement and preservation of the nearly 30,000 tissue specimens collected during the GTEx project. Furthermore, differences in the degree of autolysis and RNA integrity number were observed among the 40 tissue types evaluated, and tissue-specific susceptibilities to the duration of postmortem interval and rapidity of death were observed.
        Histologic and Quality Assessment of Genotype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection
        Leslie Sobin, MD; Mary Barcus, MD; Philip A. Branton, MD; Kelly B. Engel, PhD; Judy Keen, PhD; David Tabor, BA; Kristin G. Ardlie, PhD; Sarah R. Greytak, PhD; Nancy Roche, PhD; Brian Luke, PhD; Jim Vaught, PhD; Ping Guan, PhD; Helen M. Moore, PhD
        Arch Pathol Lab Med (2024)
        https://doi.org/10.5858/arpa.2023-0467-OA
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        RNA PAXgene Bone Marrow RNA Tube PAXgene Bone Marrow RNA Kit
        06/18/2024 | Publications Saliva RNA
        See here how NIH GTEx project successfully used the PAXgene Tissue System for tissue fixation and nucleic acid isolation from various sample types
        June 2024
        Have you heard before of the Common Fund´s Genoytpe-Tissue Expression (GTEx) Program of the National Institutes of Health (NIH)? It was established as a data resource and tissue bank to study the relationship between genetic variants (inhered changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals.
        GTEx collected approximately 40 different tissues types (i.e. brain, heart, lung, breast, skin and whole blood etc.) from nearly 1000 postmortem donors and over 30,000 samples. The developed biobank serves as a respository for GTEx biospecimen whereas most samples are preserved as PAXgene-fixed (PF), frozen samples, PAXgene-fixed, paraffin-embedded (PFPE) blocks used for histological examination or RNA from PF-tissue for RNA sequencing. The GTEx biobank also features an electronic image library of the tissue samples for researchers to browse the complete collection. Tissue-specific differences in the severity of autolysis, tissue purity and RNA integrity were evaluated, as were potential relationships between these markers and the duration of postmortem interval and rapidity of death.
        The below publication summarizes the tissue-specific challenges in the procurement and preservation of the nearly 30,000 tissue specimens collected during the GTEx project. Furthermore, differences in the degree of autolysis and RNA integrity number were observed among the 40 tissue types evaluated, and tissue-specific susceptibilities to the duration of postmortem interval and rapidity of death were observed.
        Histologic and Quality Assessment of Genotype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection
        Leslie Sobin, MD; Mary Barcus, MD; Philip A. Branton, MD; Kelly B. Engel, PhD; Judy Keen, PhD; David Tabor, BA; Kristin G. Ardlie, PhD; Sarah R. Greytak, PhD; Nancy Roche, PhD; Brian Luke, PhD; Jim Vaught, PhD; Ping Guan, PhD; Helen M. Moore, PhD
        Arch Pathol Lab Med (2024)
        https://doi.org/10.5858/arpa.2023-0467-OA
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June 2024

Have you heard before of the Common Fund´s Genoytpe-Tissue Expression (GTEx) Program of the National Institutes of Health (NIH)? It was established as a data resource and tissue bank to study the relationship between genetic variants (inhered changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals.

GTEx collected approximately 40 different tissues types (i.e. brain, heart, lung, breast, skin and whole blood etc.) from nearly 1000 postmortem donors and over 30,000 samples. The developed biobank serves as a respository for GTEx biospecimen whereas most samples are preserved as PAXgene-fixed (PF), frozen samples, PAXgene-fixed, paraffin-embedded (PFPE) blocks used for histological examination or RNA from PF-tissue for RNA sequencing. The GTEx biobank also features an electronic image library of the tissue samples for researchers to browse the complete collection. Tissue-specific differences in the severity of autolysis, tissue purity and RNA integrity were evaluated, as were potential relationships between these markers and the duration of postmortem interval and rapidity of death.

The below publication summarizes the tissue-specific challenges in the procurement and preservation of the nearly 30,000 tissue specimens collected during the GTEx project. Furthermore, differences in the degree of autolysis and RNA integrity number were observed among the 40 tissue types evaluated, and tissue-specific susceptibilities to the duration of postmortem interval and rapidity of death were observed.

Histologic and Quality Assessment of Genotype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection
Leslie Sobin, MD; Mary Barcus, MD; Philip A. Branton, MD; Kelly B. Engel, PhD; Judy Keen, PhD; David Tabor, BA; Kristin G. Ardlie, PhD; Sarah R. Greytak, PhD; Nancy Roche, PhD; Brian Luke, PhD; Jim Vaught, PhD; Ping Guan, PhD; Helen M. Moore, PhD
Arch Pathol Lab Med (2024)

https://doi.org/10.5858/arpa.2023-0467-OA

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