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Have a look at this compelling publication showing clinical predominance of whole-exome sequencing to evaluate microsatellite instability status

The microsatellite instability (MSI)/mismatch repair (MMR) status is one of the critical genomic biomarkers for predicting patient response to immune checkpoint inhibitors (ICIs). In this study, scientists aimed to investigate the concordance among the MSI sensor score obtained from whole-exome sequencing (WES), which could be a futuristic clinical cancer sequencing method, using only tumor tissues, MSI-PCR results, and immunohistochemistry (IHC) results to analyze various solid cancer types. 

Read More: Clinical predominance of whole‐exome sequencing to evaluate microsatellite instability status - Takamatsu - Cancer Science - Wiley Online Library

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