This feature highlights the significance of liquid biopsies as an emerging tool for oncology diagnostics, NIPT testing and monitoring transplantation patients through a simple blood / urine / saliva draw. There is increasing awareness that the largest contribution to diagnostic errors is from the pre-analytical workflow earlier on in the workflow. Uwe discusses the importance of choosing the best solution from sample collection to analytical assay / test for a more standardized, validated reliable diagnostic outcome with higher sensitivity, specificity and accuracy.