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Circulating cell-free DNA (ccfDNA)

An important biomarker for non-invasive prenatal testing (NIPT) and liquid biopsy, circulating cell-free DNA (ccfDNA) is obtainable through a regular blood draw. ccfDNA from plasma has the ability to provide a breadth of information to researchers and clinicians.

Did you know?

  • ccfDNA is present in low quantity in blood
  • ccfDNA can be further diluted by genomic DNA (gDNA) from apoptotic or lysed blood cells
  • The type of anticoagulant and crosslinking reagents in blood collection tubes can impact the quality of ccfDNA

Standardize your preanalytical workflow with the PAXgene Blood ccfDNA Tube (CE-IVD)
to preserve the ccfDNA profile in your blood sample


Blood collection and stabilization for reliable downstream assay performance


Stabilization chemistry matters

Learn about the non-crosslinking stabilization chemistry in the PAXgene Blood ccfDNA Tube (CE-IVD) and how other tubes may impact analytical sensitivity in downstream reactions.
 

Trusted quality samples with PreAnalytiX

Learn more about optimal quantification methods, reliable stability claims and shelf life of the PAXgene Blood ccfDNA Tube (CE-IVD) which is supported by robust experimental data.  

Applications

Non-invasive prenatal testing (NIPT)

Clinicians and researchers in the field of non-invasive prenatal testing analyze fetal DNA present among maternal ccfDNA from blood of a pregnant woman to determine the risk that the fetus will be born with certain genetic abnormalities.

Liquid Biopsy

Liquid biopsy is a minimally-invasive method of collecting a patient biofluid sample to test for biomarkers of disease. Liquid biopsy is commonly used for many applications in cancer research and diagnostics.

Click here to learn more about QIAGEN's manual and automated Sample to Insight workflows for liquid biopsy and cancer research applications.


Meet our experts on upcoming events to discuss the possibilities how to optimize your preanalytical workflows

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Watch our recent ccfDNA webinar by PreAnalytiX scientist Dr. Andrea Ullius focusing on "Considerations when generating diagnostic samples for ccfDNA analysis"

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Discover the variety of scientific publications in which the PAXgene Blood ccfDNA stabilization technology was used

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PAXgene Blood ccfDNA Tube (CE-IVD) is for in vitro diagnostic use.

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