PreAnalytiX: Have a look at this interesting paper about metabolomic and proteomic analyses of tissue specimens by MALDI MSI using the PAXgene Tissue System!

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        10/20/2017 | Publications
        Have a look at this interesting paper about metabolomic and proteomic analyses of tissue specimens by MALDI MSI using the PAXgene Tissue System!
        In this study, a comparison was done between PAXgene and standard formalin fixation for metabolomic analysis by MALDI mass spectrometry imaging.
        PAXgene was able to spatially preserve metabolites in organs achieving an overlap of common metabolites and similar signal intensities and visualization of molecules were demonstrated comparing Formalin-fixed, paraffin-embedded (FFPE) and PAXgene-fixed, paraffin-embedded (PFPE) tissue. Furthermore, metabolite and peptide profiles obtained from PFPE tissues were able to correctly classify organs independent of the fixation method, whereas a distinction of organs by protein profiles was only achieved by PAXgene fixation. Results indicated that PAXgene can be used as an alternative fixative for multi-omic tissue analysis.
        PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.
        Urban C, Buck A, Siveke JT, Lordick F, Luber B, Walch A, Aichler M.
        Biochim Biophys Acta 2017 Oct 9. pii: S0304-4165(17)30326-4. doi: 10.1016/j.bbagen.2017.10.005
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        10/20/2017 | Publications
        Have a look at this interesting paper about metabolomic and proteomic analyses of tissue specimens by MALDI MSI using the PAXgene Tissue System!
        In this study, a comparison was done between PAXgene and standard formalin fixation for metabolomic analysis by MALDI mass spectrometry imaging.
        PAXgene was able to spatially preserve metabolites in organs achieving an overlap of common metabolites and similar signal intensities and visualization of molecules were demonstrated comparing Formalin-fixed, paraffin-embedded (FFPE) and PAXgene-fixed, paraffin-embedded (PFPE) tissue. Furthermore, metabolite and peptide profiles obtained from PFPE tissues were able to correctly classify organs independent of the fixation method, whereas a distinction of organs by protein profiles was only achieved by PAXgene fixation. Results indicated that PAXgene can be used as an alternative fixative for multi-omic tissue analysis.
        PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.
        Urban C, Buck A, Siveke JT, Lordick F, Luber B, Walch A, Aichler M.
        Biochim Biophys Acta 2017 Oct 9. pii: S0304-4165(17)30326-4. doi: 10.1016/j.bbagen.2017.10.005
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        10/20/2017 | Publications
        Have a look at this interesting paper about metabolomic and proteomic analyses of tissue specimens by MALDI MSI using the PAXgene Tissue System!
        In this study, a comparison was done between PAXgene and standard formalin fixation for metabolomic analysis by MALDI mass spectrometry imaging.
        PAXgene was able to spatially preserve metabolites in organs achieving an overlap of common metabolites and similar signal intensities and visualization of molecules were demonstrated comparing Formalin-fixed, paraffin-embedded (FFPE) and PAXgene-fixed, paraffin-embedded (PFPE) tissue. Furthermore, metabolite and peptide profiles obtained from PFPE tissues were able to correctly classify organs independent of the fixation method, whereas a distinction of organs by protein profiles was only achieved by PAXgene fixation. Results indicated that PAXgene can be used as an alternative fixative for multi-omic tissue analysis.
        PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.
        Urban C, Buck A, Siveke JT, Lordick F, Luber B, Walch A, Aichler M.
        Biochim Biophys Acta 2017 Oct 9. pii: S0304-4165(17)30326-4. doi: 10.1016/j.bbagen.2017.10.005
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In this study, a comparison was done between PAXgene and standard formalin fixation for metabolomic analysis by MALDI mass spectrometry imaging.

PAXgene was able to spatially preserve metabolites in organs achieving an overlap of common metabolites and similar signal intensities and visualization of molecules were demonstrated comparing Formalin-fixed, paraffin-embedded (FFPE) and PAXgene-fixed, paraffin-embedded (PFPE) tissue. Furthermore, metabolite and peptide profiles obtained from PFPE tissues were able to correctly classify organs independent of the fixation method, whereas a distinction of organs by protein profiles was only achieved by PAXgene fixation. Results indicated that PAXgene can be used as an alternative fixative for multi-omic tissue analysis.

PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.

Urban C, Buck A, Siveke JT, Lordick F, Luber B, Walch A, Aichler M.

Biochim Biophys Acta 2017 Oct 9. pii: S0304-4165(17)30326-4. doi: 10.1016/j.bbagen.2017.10.005

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